Blood · Thrombotic thrombocytopenic purpura

PLASMIC score

How likely TTP is, in a patient with fragments and low platelets.

TellTTP clots the small vessels with platelets because the enzyme that trims von Willebrand factor is missing. The score separates it from the other causes of fragments.

Platelets under 30,000 per µL+1
Hemolysis: reticulocytes over 2.5%, undetectable haptoglobin, or indirect bilirubin over 2 mg/dL+1
No active cancer (none treated in the past year)+1
No solid organ or stem cell transplant+1
MCV under 90 fL+1
INR under 1.5+1
Creatinine under 2.0 mg/dL+1

0 of 7

Low probability

TTP is less likely. Work through the other causes of fragments: DIC, HUS, malignant hypertension, a valve, a drug.

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